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Journal of Human Lactation
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Transfer of Interferon Alfa Into Human Breast Milk

Anil R. Kumar, MD

Thomas W. Hale, RPh, PhD

Texas Tech University School of Medicine, 1400 Wallace Boulevard, Amarillo, TX 79106, USA

Richard E. Mock, PhD

Texas A&M Veterinary Medical Diagnostic Laboratories; Veterinary Medical Virology Laboratory

Originally assumed to be antiviral substances, the efficacy of interferons in a number of pathologies, including malignancies, multiple sclerosis, and other immune syndromes, is increasingly recognized. This study provides data on the transfer of interferon alfa (2B) into human milk of a patient receiving massive intravenous doses for the treatment of malignant melanoma. Following an intravenous dose of 30 million IU, the amount of interferon transferred into human milk was only slightly elevated (1551 IU/mL) when compared to control milk (1249 IU/mL). These data suggest that even following enormous doses, interferon is probably too large in molecular weight to transfer into human milk in clinically relevant amounts.

Key Words: interferon alfa • human milk • breastfeeding • melanoma

Journal of Human Lactation, Vol. 16, No. 3, 226-228 (2000)
DOI: 10.1177/089033440001600308
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Committee on Drugs
The Transfer of Drugs and Other Chemicals Into Human Milk
Pediatrics, September 1, 2001; 108(3): 776 - 789.
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