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Journal of Human Lactation
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Estimation of Neonatal Exposure After Accidental Ingestion of Lufenuron in a Breastfeeding Mother

Benjamin Bar-Oz, MD

Department of Neonatology, Hadassah University Hospital, Jerusalem, Israel

Shinya Ito, MD

Breastfeeding Program; Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada

Vic Parks, DVM, MBA

Novartis Animal Health Canada Inc.

Max P. Maurer, PhD

Novartis Animal Health Research Center in St. Aubin, Switzerland

Gideon Koren, MD

Hospital for Sick Children; University of Toronto

A case of accidental anti-flea preparation (lufenuron) ingestion by a breastfeeding mother is reported. An estimation of infant exposure level was calculated based on the highest level measured. The breastfed infant was exposed to an average lufenuron dose of 0.032 mg/kg/day, which is only 3% of a reported acute overdose. No adverse effects were reported during 7 months of follow-up. Breastfeeding should be considered cautiously after consultation with a regional poison center in cases of accidental ingestion of this drug by a breastfeeding mother. The infant should be monitored for potential adverse effects.

Key Words: lufenuron • ingestion • breastfeeding

Journal of Human Lactation, Vol. 16, No. 3, 229-230 (2000)
DOI: 10.1177/089033440001600309
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