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Journal of Human Lactation
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Use of Anti-Infective Agents During Lactation: Part 1—Beta-Lactam Antibiotics, Vancomycin, Quinupristin-Dalfopristin, and Linezolid

Karen G. Chin, PharmD, BCPS

University of Illinois at Chicago, Department of Pharmacy Practice, M/C886, 833 S. Wood Street, Room164, Chicago, IL 60612, USA.

Christina Mactal-Haaf, PharmD, BCPS

Charles E. McPherson, III, PharmD

University of Illinois at Chicago College of Pharmacy; University of Illinois at Chicago Hospital.

Because many antibiotics are excreted into the breast milk, it can be difficult for a practitioner to choose an antibiotic for a lactating patient that will have minimal risks to her nursing infant. This article is the first of a three-part series discussing the use of anti-infective agents during lactation. The authors review general information regarding use and common side effects of several classes of antibiotics. They also summarize information, including documented milk concentrations, milk-to-plasma ratios, and other pharmacokinetic properties, in a table that can help practitioners choose antibiotics that may be considered safe for the lactating mother.

Key Words: lactation • breastfeeding • human milk • anti-infectives

Journal of Human Lactation, Vol. 16, No. 4, 351-358 (2000)
DOI: 10.1177/089033440001600413
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 J Hum LactHome page
K. G. Chin, C. E. McPherson III, M. Hoffman, A. Kuchta, and C. Mactal-Haaf
Use of Anti-Infective Agents During Lactation: Part 2--Aminoglycosides, Macrolides, Quinolones, Sulfonamides, Trimethoprim, Tetracyclines, Chloramphenicol, Clindamycin, and Metronidazole
J Hum Lact, February 1, 2001; 17(1): 54 - 65.
[Abstract] [PDF]