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Use of Anti-Infective Agents During Lactation: Part 2—Aminoglycosides, Macrolides, Quinolones, Sulfonamides, Trimethoprim, Tetracyclines, Chloramphenicol, Clindamycin, and Metronidazole

University of Illinois at Chicago College of Pharmacy; University of Illinois at Chicago Hospital; University of Illinois at Chicago, Department of Pharmacy Practice, M/C 886, 833 S. Wood Street, Room 164, Chicago, IL 60612, USA.;

Charles E. McPherson, III, PharmD

Maria Hoffman, PharmD

Ann Kuchta, PharmD

Christina Mactal-Haaf, PharmD, BCPS

University of Illinois at Chicago College of Pharmacy; University of Illinois at Chicago Hospital.

Because many antibiotics are excreted into breast milk, it can be difficult for a practitioner to choose an antibiotic for a lactating patient that will have minimal risks to her nursing infant. This article is the second of a three-part series discussing the use of anti-infective agents during lactation. The authors review general information regarding use and common side effects for several classes of antibiotics. They also summarize information, including documented milk concentrations, milk-to-plasma ratios, and other pharmacokinetic properties, in a table that can help practitioners choose antibiotics that may be considered safe to use in the lactating mother.

Key Words: lactation • breastfeeding • human milk • anti-infectives

Journal of Human Lactation, Vol. 17, No. 1, 54-65 (2001)
DOI: 10.1177/089033440101700111


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