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Journal of Human Lactation
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*Antidepressants
*High Risk Pregnancy
*Postpartum Care
*Postpartum Depression
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Antidepressant Use During Lactation

Elizabeth A. Winans, PharmD, BCPP

University of Illinois College of Pharmacy and Department of Psychiatry; Psychiatric Clinical Research Center, University of Illinois at Chicago, 1601 W. Taylor, 4th Floor, Chicago, IL 60612, USA.

Depression commonly affects women, particularly during their childbearing years. Often, pharmacologic therapy is the recommended treatment. Today, medication selection generally involves the newer antidepressants, with tricyclic antidepressant and monoamine oxidase inhibitors reserved for more refractory patients. Although there is ample evidence to support the benefits of breastfeeding in the infant, the scientific literature contains little information with regard to the transfer of antidepressants from the plasma into breast milk and the subsequent effects on the developing infant. Secondary to this lack of safety data, many clinicians and mothers are reluctant to breastfeed during antidepressant treatment. This article will review the literature for reports of the newer antidepressants' use during lactation.

Key Words: antidepressants • lactation • breastmilk

Journal of Human Lactation, Vol. 17, No. 3, 256-261 (2001)
DOI: 10.1177/089033440101700309
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Home page
 J Am Board Fam MedHome page
D. Gjerdingen
The Effectiveness of Various Postpartum Depression Treatments and the Impact of Antidepressant Drugs on Nursing Infants
J Am Board Fam Med, September 1, 2003; 16(5): 372 - 382.
[Abstract] [Full Text]