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Journal of Human Lactation
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Gabapentin and Breastfeeding: A Case Report

Judith H. Kristensen, BPharm

Department of Pharmacy at the Women’s and Children’s Health Service, Subiaco, Western Australia

Kenneth F. Ilett, BPharm, PhD

Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia

L. Peter Hackett, MRSC

Clinical Pharmacology & Toxicology Laboratory at PathWest Laboratory Medicine, Nedlands, Australia

Rolland Kohan, MBBS, FRACP

Department of Neonatal Services at the Women’s and Children’s Health Service, Subiaco, Western Australia

The aim of this study was to describe the milk-plasma ratio and relative infant dose of gabapentin in a breastfeeding mother and to determine the well-being of her exposed infant. The mother-infant pair was studied over a 24-hour dose interval at steady state. Gabapentin concentrations were quantified by high-performance liquid chromatography. Infant exposure was calculated as concentration in milk multiplied by an estimated milk production of 0.15 L/kg/d and normalized to the weight-adjusted maternal dose. The milk-plasma ratio was 0.86; the relative infant dose was 2.34%. The absolute infant dose was approximately 3% of the children’s dose for gabapentin, and the infant plasma level of 0.4 mg/L was approximately 6% of the maternal plasma drug concentration. No adverse effects attributable to gabapentin were noted in the infant. In combination with a previously published report, these limited data support the prescription of gabapentin to a breastfeeding mother after a careful individual risk-benefit analysis.

Key Words: gabapentin • human milk • relative infant dose • breastfeeding

Journal of Human Lactation, Vol. 22, No. 4, 426-428 (2006)
DOI: 10.1177/0890334406293421
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